All CBC parameters in diagnosis of acute appendicitis

Objective: To investigate leukocyte count, neutrophil percentage, Neutrophil-Lymphocyte Ratio (NLR), Platelet-Lymphocyte ratio (PLR), mean platelet volume (MPV), red cell distribution width (RDW), platelet distribution width (PDW) and CRP in the diagnosis of acute appendicitis (AA). Materials and methods: A retrospective case-controlled study was designed in two groups. Ninety-seven patients containing AA and 94 patients in control group. Leukocyte count, neutrophil percentage, NLR, PLR, MPV, RDW, PDW and CRP were compared in two groups. Results: The mean PLR values in AA and control were 166±97 and 107±28 respectively, and there was a significant difference in PLR values between the groups (P<0.0001). Best cutoff point for WBC count in the diagnosis of AA was 8650 106/μL, which had a sensitivity of 76% and a specificity of 94%. Best cutoff in diagnosis AA for NLR 3.15, which had a sensitivity of 77% and a specificity of 94%. Acute appendicitis group having low levels in MPV and RDW values but there were no significant differences in two groups. Leukocyte levels correlated with NLR, PLR and PDW. Conclusion: Neutrophil-Lymphocyte Ratio and leukocyte count seems to be a better inflammatory marker in AA. Higher PLR levels important parameter in diagnosis of AA. However, ROC analysis showed that MPV and RDW levels is not marker in terms of sensivity and specifity compared to other markers.